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Dose escalation and symptom patterns Each dose increase on a GLP-1 medication can trigger a new round of sulfur burps

PIONEER 9 was a 52-week, phase 2/3a, randomized, controlled trial to assess the efficacy, dose response, and safety of oral semaglutide monotherapy (3, 7, or 14 mg) compared with placebo and liraglutide 0.9 mg in 243 Japanese patients with type 2 diabetes uncontrolled on diet and exercise or one oral glucose-lowering drug (washed out during run-in) [52]

You should reach out if nausea or vomiting is severe, persistent, or makes it difficult to keep fluids down

What to Watch For : If you have a history of heart disease, closely monitor your symptoms