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TLR4 expression is increased (1.9-fold) in the squamous epithelium of patients with RE compared to normal esophageal squamous epithelium (50)
Glutathione also suppresses the melanin production that can lead to hyperpigmentation (dark spots) in skin
The dimer form exhibited the highest binding affinity, with a binding energy of 7.9 kcal/mol and an inhibition constant of 1.595 M, significantly higher than both the monomer form (binding energy of 6.2 kcal/mol, K i of 28.21 M) and the reference inhibitor, ethacrynic acid (binding energy of 6.6 kcal/mol, K i of 14.35 M)
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