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Neuropsychiatric effects have been reported in post-marketing surveillance of GLP-1 receptor agonists, though the incidence and causal relationship remain unclear

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miR-16 and miR-223 are also identified as targets to distinguish patients with early RA from healthy individuals ( Most of the aberrant miRNA levels can alter the secretion of inflammatory cytokines or MMPs, further affecting the procession of RA

These observations help researchers form hypotheses about potential mechanisms of action, but they do not establish clinical relevance or real world outcomes