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Studies, including those published as recently as late 2025, indicate that this mechanism can lead to a reduction in fat cell size and proliferation, alongside an increase in resting metabolic rate

10.1074/jbc.M111.259978 132 SingalA

Similarly, a recent study conducted by Yip in laboratory animals using RNA-guided endonucleases Cas9 and Cpf1 using metal-coated CRISPR directed towards mGluR5 gene resulted in amelioration of repetitive behaviors of autism caused due to genomic defect of fragile X syndrome [183, 184]