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Defy's version, for example, uses thiamine (B1) where Empower uses carnitine as the headline addition

However, there remains a large gap to be filled in translating in vitro models to animal and human models

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Some of the so far reported short-term effects are accumulation of toxins on the skin, irritation, (micro) inflammation, oxygen deficiency, clogging of pores, impairment of skin barrier, dryness / lack of moisture, excessive desquamation, pigment spots, altered metabolism as well as protein, lipid, and DNA oxidation