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Pretreatment with LPS/ATP exhibited a significant reduction in mitochondrial membrane potential compared with untreated cells

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GLP-1 is an incretin hormone that plays a key role in: Stimulating insulin secretion in response to food Suppressing glucagon release (which raises blood sugar) Slowing gastric emptying, which promotes a feeling of fullness Reducing appetite and food intake This is the same pathway targeted by GLP-1 receptor agonist medications though berberine acts upstream by encouraging the bodys own GLP-1 production, rather than mimicking the hormone directly

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