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In parallel, there has been growing interest in probiotics as natural, safe, and accessible dietary supplements with the potential to support performance and recovery
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Elevated intracellular calcium and possible PKC activation may collectively impact gene transcription events, presumably supporting growth hormone synthesis and secretion
Clinical studies consistently report elevated circulating and central levels of pro-inflammatory cytokines, including interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor- (TNF-), in patients with major depressive disorder, with cytokine concentrations often correlating with symptom severity, illness chronicity, and treatment resistance (30, 32)
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