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doi: 10.1016/j.molcel.2022.10.001 54 AbrahamAKattoorAJSaldeenTMehtaJL

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Scientific studies often focus on its interaction with neurochemical signaling systems associated with relaxation and restorative biological processes

Instead, it arises from a complex interplay of the following: Skin barrier dysfunction Environmental triggers Immune dysregulation Understanding these mechanisms is key to effective treatment and explains why simply moisturizing often fails to provide lasting relief