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The phase 2b ENLIVEN trial, a multicenter, randomized, double-blind, placebo-controlled study, included 222 patients with biopsy-confirmed NASH and F2-F3 fibrosis, assigned to receive pegozafermin at doses of 15 mg weekly, 30 mg weekly, 44 mg every 2 weeks, or placebo for 24 weeks

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Pooled analyses from trials such as SUSTAIN-6 and LEADER reported reductions in albuminuria and slower declines in estimated glomerular filtration rates (eGFR), with pronounced benefits observed in those with lower baseline eGFR (41)