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Cycle structure Cycle Guidelines (community-derived from compound-level data) Approach Pre-blended daily Loading Maintenance 0.52.0 mg total blend daily Total cycle 612 weeks Common context Convenience-first, steady exposure Approach Separate vials standard Loading Weeks 14 Maintenance Weeks 58 Total cycle 812 weeks Common context Loading-then-taper for injury planning Approach Separate vials extended Loading Weeks 14 Maintenance Weeks 512 Total cycle 12 weeks Common context Slower-healing tissue research planning These are research-planning structures, not treatment plans

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doi: 10.1021/acsnano.9b02875 143 ChenHMWangPHChenSSWenCCChenYHYangWCet al