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This is the hallmark of a homeostatic modulator rather than a direct agonist or antagonist

In other situations, where there are no IPPS hospitals located in a relevant labor market area, we apply our current policy of calculating an urban or rural area's wage index by calculating the average of the wage indexes for CBSAs (or metropolitan divisions where applicable) that are contiguous to the area with no wage index

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Together, they provide a platform for observing coordinated or independent pathway activity within a unified solution matrix