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Oxidative Stress in Asthma

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Women should discontinue GLP-1 medications before conception or as soon as pregnancy is confirmed, with semaglutide requiring cessation at least 2 months before planned pregnancy

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The novel mechanism by which 4-HNE inhibits NLRP3 is through its ability to directly bind to the critical domains of NLRP3, disrupting its interaction with the adapter protein NEK7, a key step in inflammasome activation, thereby preventing caspase-1 activation

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