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"CJC-1295 and GHRH analogs for therapeutic growth hormone release." Clin Interv Aging

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doi: 10.3390/ijms19030862 58 Otulak-KozieK.KozieE.LockhartB

Muscle atrophy and sports medicine research&Wound healing and tissue engineering Indications: muscular dystrophy, AIDS related muscle consumption, muscle atrophy caused by long-term bed rest.Experimental Design:Animal model: Rats were subcutaneously injected with 0.1-0.3 mg/kg IGF-1 LR3, three times a week for 12 weeks, and the results showed a 15-20% increase in muscle strength.Cell experiment: In the myotube culture system, IGF 1 LR3 1mg can induce upregulation of myosin heavy chain (MyHC) expression and promote muscle fiber type transformation