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This pharmacokinetic profile supports once-weekly dosing, allowing steady-state levels to build over the first 45 weeks of treatment

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The main limitations of this study were its small size and short duration, as well as its open-label design

In recent years, emerging allosteric modulators have been developed that recognize allosteric sites other than orthosteric sites and modulate receptor activation by changing the conformation of the receptor 7,8 , which has the advantages of high selectivity, overcoming resistance to orthosteric modulators, and expanding the concept of target sites