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Most ferroptosis inducers such as Erastin and RSL3, are inhibitors of System X c /GSH/GPX4 axis, which provide a good basis for us to understand the role of different antioxidants in inhibiting ferroptosis ( Since tumor cells with certain oncogenic mutations are very sensitive to ferroptosis, triggering ferroptosis may also have significant therapeutic potential for ferroptosis-sensitive tumor cells ( c /GSH/GPX4 axis have been shown to be fatal in host cells

As part of selenoproteins, Se takes an active part in antioxidant, redox and anti-inflammatory processes (59)