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The combination of these mechanisms could explain the superior glycemic control observed with tirzepatide compared to GLP-1 receptor agonists alone

Importantly, weight regain is minimal during the first year of consistent treatment, making early months particularly valuable for habit formation

Irreversible heat inactivation of DNase I without RNA degradation

In addition to controlling obesity and type 2 diabetes, two key cardiovascular risk factors, GLP-1RAs may stabilise atherosclerotic plaques, mitigate post-prandial hyperlipidaemia, and reduce sympathetic nervous system activity that contributes to elevated blood pressure