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AMPAkines increase channel open time without directly activating the receptor, and may also elevate neurotrophic factors such as BDNF (brain-derived neurotrophic factor), contributing to neuronal survival and synaptic remodeling [207]

This novel gene-nutrient interaction with implications for blood pressure management is important in public health terms, given that the frequency of the variant MTHFR 677TT genotype is 1012 % in the UK and Ireland but it varies according to the geographical area with the highest frequency of 3244 % is reported in Mexico (Reference Wilcken, Bamforth and Li115Reference Reyes, Godfrey and Ming117)

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Maintaining gradual rather than precipitous weight loss, ensuring adequate hydration, and avoiding prolonged fasting may help, but these approaches have not been specifically validated in patients taking these medications