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Furthermore, researchers have shown that glutamine antagonists can inhibit cancer cell oxidative and glycolytic metabolism, thereby reducing tumor hypoxia, acidosis, and nutrient consumption

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Another key strength is the study design, which minimized biases related to the inclusion of prevalent users without excluding patients with a history of self-harm or suicidal ideation

This review comprehensively examines the central role of gut microbiota in PCOS pathogenesis, including shifts in microbial communities such as bacteria, fungi, and viruses, and their impact on critical metabolites like short-chain fatty acids, bile acids, and tryptophan metabolites, which modulate host metabolism and reproductive function