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doi: 10.1016/j.semnephrol.2012.04.009

found close relationships between GPX4 and DKD, including urinary protein, Scr, eGFR, and the percentage of sclerosed glomeruli in renal specimens

Tolerability: Adverse events mainly include mild nasal irritation in 10%-15% of subjects (example: transient congestion or mild discomfort), with no serious adverse events documented by trial sponsors and researchers

In certain embodiments of such auris-compatible formulations or compositions that comprise a dye, the ability to visualize a controlled release otic formulation or composition comprising a dye allows for testing of any otic formulation described herein in human clinical trials