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The expression of nNOS in cardiac tissue allows it, through the production of NO, to play essential roles in the modification of sympathetic and parasympathetic tone within the heart itself, in the regulation of heart rate, and in the delivery of essential nutrients through the coronary arteries as well as through the regulation of myocardial contractility

Acute systemic LPS injections induce pronounced but reversible changes in astrocyte gene expression in the prefrontal cortex, along with an approximate 25% decrease in astrocyte branch and process volumes, but with few currently detectable changes in astrocyte physiology and basic preservation of astrocyte core homoeostatic functions such a potassium buffering

Palmeros-Surez et al., 2021)

The single-dose approach remains debated among experts