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Abbreviations BC: breast cancer TAM: tumor-associated macrophages CCL5: C-C motif chemokine ligand 5 CCR1/3: chemokine receptor 1/3 VCAM-1: vascular cell adhesion molecule 1 E-cig: E-cigarettes CS: cigarette smoking MMPs: matrix metalloproteinases VEGF: vascular endothelial growth factor TNF: tumor necrosis factor EVC: E-cigarette vapor condesate Declarations Acknowledgement None

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Systemic diseases [edit] There are a few systemic (non-oral) medical conditions that may cause foul breath odour, but these are infrequent in the general population

Chewing Tobacco AGD researchers noted that the carcinogenic properties of chewing tobacco is even more potent than cigarettes