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In these experiments, semaglutide together with alcohol increased the NAc gene expression of MAOA (t (8) = 2.38, P = 0.0447, unpaired t-test) and COMT (t (8) = 6.41, P = 0.0002, unpaired t-test), but not MAOB (t (8) = 0.83, P = 0.4322, unpaired t-test) or DAT (t (8) = 0.0002, P = 0.9966, unpaired t-test) compared to alcohol (Fig

After this, attempt to increase the dose back to 2.4 mg

The development of an oral GLP-1RA represents a significant milestone in the management of T2D, providing an additional efficacious treatment option for patients