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Abbreviations ACC: American College of Cardiology AHA: American Heart Association AN: Anorexia Nervosa APGAR: Adaptability, Partnership, Growth, Affection, and Resolve BED: Binge Eating Disorder BES: Binge Eating Scale BIQLI: Body Image Disturbance Questionnaire BMBF: Federal Ministry of Education and Research BMI: Body Mass Index BN: Bulimia Nervosa CBT: Cognitive Behavioral Therapy DATO: Dutch Audit for Treatment of Obesity EASO: European Association for the Study of Obesity EMA: The European Medicines Agency FDA: U.S

In summary, this study revealed that dysfunction of cellular transport of cytoplasmic FA to mitochondria plays a critical role in UA-induced cardiomyocyte injury and thereby promotes LVR development and identified CPT1B as the key factor influenced by UA

Acknowledgements The authors are thankful to the Department of Science and Technology and Biotechnology, GoWB, India for support to U.C