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Annu Rev Pharmacol Toxicol

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Cigarette smoke disrupts gutlung axis communication through microbial metabolite alterations driving pulmonary inflammation and cancer progression Interestingly, accumulating investigations demonstrate that cigarette smoke distorts gutlung axis communication by altering microbial metabolite profiles, creating a pro-inflammatory milieu that fuels pulmonary deterioration in COPD and promotes oncogenic niches in lung adenocarcinoma (LUAD)

Smoking boomed in the first half of the twentieth century, thanks to heavy advertising and the inclusion of cigarettes as part of soldiers rations during the two world wars