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In the SURPASS clinical trial program, gastrointestinal adverse events were generally mild to moderate in severity and tended to decrease over time as patients developed tolerance to the medication

Despite these differences, patients often report similar experiences: Providers evaluate each patients goals, medical history, insurance coverage, and treatment preferences before recommending one medication over another

Cholangitis: If a stone blocks the common bile duct, bile backs up into the liver, causing a severe bacterial infection characterized by fever, jaundice, and shock

Consult your doctor if you experience serious side effects