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For the other claims, the applicant provided only background evidence, specifically retrospective studies, which describe findings for a predicate device, the Axoguard Nerve Protector TM , which received FDA 510(k) clearance on January 10, 2014, not the nominated device, the Axoguard HA+ Nerve Protector TM

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3, IGF-1R was distributed in cytosol, membrane and nuclear fractions of all the cell lysates

Finding the proper chemical compounds that could activate the expression of appropriate histone demethylases and thus stimulate neuronal determination programs would be of tremendous significance for efficient neuronal regeneration after injuries in non-neurogenic regions of the adult brain