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On the other hand, signaling pathways and transcription factors implicated in WAT differentiation and lipid storage may include CCAAT enhancer binding protein alpha (C/EBP), sterol regulatory element binding transcription factor 1 (SREBP1), peroxisome proliferator-activated receptor- (PPAR) and SIRT1 [49,75,76]

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It just means that in clinical trials, midlife women are grouped into broader categories, making it hard to draw firm conclusions about how well GLP-1s work for this unique stage of life as compared to other populations