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Additive effect on kidney outcomes including macroalbuminuria was also expected from AMPLITUDE-O substudy, however, additive effect of semaglutide and SGLT2i on the composite kidney outcomes without macroalbuminuria was not indicated in the FLOW substudy [50]

However, due to their efficacy in inducing body-weight loss, extensive evidence with high doses of GLP-1R agonists have demonstrated clinically relevant and sustained effects on body weight in obesity [26]

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