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doi: 10.3389/fpsyt.2021.669089 Received 17 February 2021 Accepted 16 August 2021 Published 30 September 2021 Volume 12 - 2021 Edited by Francesca Bonomini, University of Brescia, Italy Reviewed by Mostafa Waly, Sultan Qaboos University, Oman

Similarly, the changes accompanying renal failure will likely influence the gut microbiota or the ecosystem of microorganisms resident in the intestine (Bartochowski et al., 2022)

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Oxidative stress affects numerous molecular pathways, including inhibition of the cystine/glutamate antiporter system, decreased expression of GPX4, disruption of iron homeostasis and lipid peroxidation, which is a major driver of ferroptosis activation (54)