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This activation produces cytokines and chemokines that attract monocytes and promote their differentiation into tumor-associated M2 macrophages, known for their pro-tumor effects

Cystine starvation has been shown to impede TNBC growth, which affects stem cell properties and chemotherapy resistance in TNBC (27), thereby promoting TNBC cell ferroptosis through activation of the general control nonderepessible 2-eukaryotic translation initiation factor 2 subunit 1-activating transcription factor 4-CHAC1 pathway through the specific cytosolic GSH degradation enzyme CHAC1 (28)

they are not interchangeable and are presented solely to demonstrate the calculation

J Biol Chem 251 : 42874293 Pisoni RL, Acker TL, Lisowski KM, Lemons RM, Thoene JG 1990 A cysteine-specific lysosomal transport system provides a major route for the delivery of thiol to human fibroblast lysosomes: possible role in supporting lysosomal proteolysis