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LDL-C promotes coronary calcification directly through oxidation and inflammatory pathways, depositing within the vascular wall to form plaques, which subsequently induce smooth muscle cell calcification and eventually lead to stable calcified plaques [66]

Free and Fixed-Ratio Combinations of Basal Insulin and Glp-1 Receptor Agonists Versus Basal Insulin Intensification in Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

In the subgroup at high cardiovascular risk, effect estimates were similar (HR 0.80, 95% CI 0.71 to 0.91)