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The neuroinflammatory cascade following the excitotoxic insults within the CNS also affect GABA receptor-mediated inhibitory signalling by eliminating GABAergic synapses, thus exacerbating the imbalance in the neuronal excitation/inhibition and possibly contributing to the NVU dysfunction (i.e., BBB disruption) [232]

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Jones, N.L., Roifman, C.M., Griffiths, A.M

On April 30, 2026, the FDA proposed permanently removing semaglutide, tirzepatide, and liraglutide from the list of substances large outsourcing facilities may compound in bulk, with a public comment period open through late June 2026