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These medications, such as Liraglutide (Victoza) or Semaglutide (Ozempic), work by mimicking the effects of a naturally occurring hormone called glucagon-like peptide-1 (GLP-1)

Unlike single-agonist incretin analogs, tirzepatide was engineered to engage two distinct class B G protein-coupled receptors simultaneously, providing researchers with a tool to probe the additive or synergistic downstream signaling that emerges from co-activation of GLP-1R and GIPR pathways

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(iv) disturbances after hypokalemia and hyperkalemia and potassium cell membrane dysfunction