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The most reported side effects include: Nausea Diarrhoea Vomiting Mild stomach discomfort Importantly, no cases of severe hypoglycemia or fatalities were reported during clinical trials, and most side effects were resolved without needing to stop the medication

Furthermore, the study carefully selects trials that focus exclusively on the GI adverse effects of GLP-1 RA in RCTs involving adults with overweight or obesity

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GLP-1 medications require careful evaluation in patients with Crohn's disease, as gastrointestinal effects may interact unpredictably with active or remission-phase inflammation