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Instead, he advised baseline retinal examinations in patients with diabetes before initiating therapy and closer monitoring for those with severe NPDR or proliferative DR during periods of rapid glycemic improvement (Figure 3)

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Thus, it is likely that the most efficient way to achieve a reduction in food intake would have to involve a simultaneous impact on a number of CNS regions controlling different aspects of feeding regulation from the cognitive, decision-making, memory, and rewarding aspects to the feeling of satiety and hunger