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There was no apparent effect of renal impairment, hepatic impairment or upper GI disease on the PK and tolerability of orally administered semaglutide, suggesting that dose adjustment is not necessary in these special populations [11, 31,32,33]

Importantly, while the incidence of adverse effects was similar between ALC and placebo/no intervention, ALC was associated with a lower incidence of adverse effects compared to antidepressant medications