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Abstract Sodium-glucose cotransporters inhibitors (SGLT2-i) and GLP-1 receptor agonists (GLP1-RA) are glucose-lowering drugs that are proved to reduce the cardiovascular (CV) risk in type 2 diabetes mellitus (T2DM)

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Collectively, these data suggest that in the multistep metabolism of dietary l-carnitine into TMAO (i.e., l-carnitineBBTMATMAO), gut microbial metabolism of l-carnitineBB occurs rapidly in omnivore and vegan/vegetarian alike, and the latter microbial transformation of BB to TMA is the one markedly enhanced in omnivores over vegans/vegetarians (i.e., influenced by chronic dietary habits