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Experts Urge Long-Term Strategies Beyond Medication Based on the findings, the authors conclude: "This evidence cautions against short term use of weight management medications, emphasizes the need for further research into cost effective strategies for long term weight control, and reinforces the importance of primary prevention." A US researcher echoed these concerns in a linked editorial, writing that "The study findings cast doubt on the notion that GLP-1 receptor agonists are a perfect cure for obesity." "People taking GLP-1 receptor agonists should be aware of the high discontinuation rate and the consequences of cessation of medications," he adds

Rab GTPases as coordinators of vesicle traffic

Instead, the role of PKC in mediating lipid-induced hepatic insulin resistance is thought to be related to altered adipose PKC crosstalk with the liver (68)