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This is consistent with previous findings that -cell plasticity occurs in common forms of -cell dysfunction, and is caused by the downregulation of FoxO1 that follows hyperglycemia-induced oxidative stress 26

10.1016/S0378-4347(00)81869-1

A meta-analysis of randomized, controlled trials found that DHEA supplementation significantly decreased cortisol levels (Chen 2021)

When NNMT is too active, it consumes our precious supply of NAD+ (nicotinamide adenine dinucleotide), a coenzyme that is absolutely essential for cellular energy production and DNA repair