The study in the NEJM showing possible benefits of semaglutide in MASH patients with advanced inflammation and fibrosis is another exciting advance in our efforts to conquer this indolent, but deadly disease.
For diabetes management, this includes HbA1c measurements every 36 months once stable, periodic review of blood glucose monitoring results, assessment of weight changes, and monitoring for signs of diabetic complications
In hepatocytes and adipocytes it reduces the activity of key lipogenic enzymes: Acetyl-CoA carboxylase (ACC) , a key step in fatty acid synthesis Fatty acid synthase (FAS) , the enzyme creating long chains of fatty acids Lipoprotein lipase (LPL) in adipocytes, reduces uptake of circulating triglycerides into fat cells Imagine it as turning valves in a pipeline, you close the inflow (lipogenesis), open the outflow (lipolysis)
Additionally, tirzepetide (branded Mounjaro/Zepbound) is an emerging GLP-1 agonist with a dual mechanism of action that targets both the GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors