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At present, it is not clear whether the neurologic effects are a result of the accumulation of a toxic metabolite, such as sulfite, or inadequate sulfate production

You can find more technical data on Nature.com regarding peptide signaling

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As GPX4 serves as the master regulator of lipid hydroperoxide reduction, its suppression triggers irreversible lipid peroxide accumulation that culminates in ferroptotic cell death (67, 68)