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Subsequently, bacteria and LPS are translocated into the liver through the portal vein, activating the TLR4/NF-B signaling pathway of liver Kupffer cells, and promoting the production of inflammatory cytokines such as TNF-, IL-6 and IL-1 (Jiang and Schnabl, 2020)
Int J Neurosci (2021) p:138
Furthermore, glucagon receptor agonism is being investigated for the treatment of NAFLD due to its appetite and food intake-reducing effects, as well as its ability to increase lipid oxidation and thermogenesis
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