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It tends to produce faster initial results but loses effectiveness as the body adapts

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Neural tube defects (i.e., a congenital malformation of the spinal cord in which the neural tube fails to close during embryogenesis and results in exposure of the unclosed spinal cord, also called spina bifida) were shown to be related to vitamin deficiencies, including folic acid deficiency (103)

Then these are sealed by sealing machine in an appropriate manner