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Genetics can also play a role, and for an individual approach we often consider variations to gene SNPs such as SLC17A7 and APOE (16, 17), that can affect how well a child calms inflammation, detoxifies, produces and clears key neurotransmitters

Further research has found that the interaction between phosphorylated nuclear factor B (NF-B) p65 and its regulator eIF2 inhibits ER stress-mediated intestinal epithelial cell ferroptosis, suggesting that NF-B p65 may be a potential therapeutic target for UC [286]

Additionally, HT patients should be educated about nutrition because a well-balanced diet is one of the most critical elements in preventing nutritional deficiencies

Biomarker assessment of glutathione and related markers like cysteine, glycine, and glutamate can reveal whether supplementation directly addresses a documented deficiency or addresses downstream metabolic stress