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4 The chemical dependence makes quitting difficult When nicotine reaches the brain, it binds to nicotinic receptors which release neurotransmitters, like dopamine

Additionally, bupropion has been proposed as a potential agent for reducing blood glucose levels, according to evidence from population-based clinical quantitative phenotyping studies (Brown et al., 2018)

They suggested the additional health risks of menthol may be more difficult to detect while someone is currently smoking given the severe harms of tobacco itself