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In addition, in an HHcy-induced 2-kidney, 1-clip (2K1C) hypertensive murine model and Hcy-B CM-treated glomerular endothelial cells (GECs), a significant increase in the ferropotosis rate was triggered through iron accumulation, lipid peroxidation, upregulation of TFR1, and downregulation of SLC7A11 and GPX4 [262]
In a dissenting comment, Sikiric and colleagues said that BPC-157 had been unjustly accused of potentially harmful effects. They pointed to a list of research findings that, in their view, rule out the possibility that the peptide causes cancer and other potential harms
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