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Breathing Control Maneuvers Keep your breathing even and natural, allowing air to flow through your nose between puffs so your body stays relaxed, and if your chest begins to feel heavy or uncomfortable, stop right away and ease the sensation by drinking a sip of cool water, which can help soothe the throat and make the experience more manageable

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Funding: This work was supported by the National Institute on Drug Abuse, part of the National Institutes of Health, under grants DP1DA056493-01 and P51OD011092