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In animal research, combined use shows improved results: Quicker formation of granulation tissue and wound closure Decreased edema and inflammation Better tendon-to-bone integration and ligament tensile load Systemic effects on the protection of distant organs, such as the liver and kidney in ischemia-reperfusion
N.BhattI.DietzK
For instance, at physiologic relative low concentrations, secondary BAs exert anti-inflammatory properties, inducing a partial transformation from M1 to M2 phenotype of macrophages and inhibiting the release of pro-inflammatory cytokines, such as TNF- and IL-6 [25]
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