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In toxicology studies, BPC 157 exhibited a negative limit test, 2 g/kg i.v

In OA models induced by interleukin-1 beta (IL-1) and ferric ammonium citrate (FAC), hallmark ferroptosis markers such as glutathione peroxidase 4 (GPX4) and solute carrier family seven member 11 (SLC7A11) exhibit significant downregulation, whereas expression levels of the tumor suppressor gene p53 and acyl-CoA synthetase long-chain family member 4 (ACSL4) are elevated (Yao et al., 2021)

This high-profile negative result cast doubt on Cerebrolysins efficacy for stroke, though subgroup analyses suggested possible benefit in severe cases