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Requirements of Vitamin B12 in excess of normal (due to pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be met with oral supplementation

Serious side effects are rare, occurring in less than 1 percent of users

Research has found a link between low vitamin B12 levels and depression, and there are several mechanisms by which this vitamin may influence mental well-being: It is involved in the production of "feel-good" hormones such as serotonin and dopamine, which greatly influence mood

Among these latter, non-alcoholic fatty liver disease (NAFLD), characterized by lipid accumulation in hepatocytes, in the absence of alcohol abuse or other steatogenic factors, is one of the most prevalent